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Xiao-Fang Che Selected Research

3-aminophenoxazone

11/20132-Aminophenoxazine-3-one-induced apoptosis via generation of reactive oxygen species followed by c-jun N-terminal kinase activation in the human glioblastoma cell line LN229.
2/2012Enhancement of cytotoxic and pro-apoptotic effects of 2-aminophenoxazine-3-one on the rat hepatocellular carcinoma cell line dRLh-84, the human hepatocellular carcinoma cell line HepG2, and the rat normal hepatocellular cell line RLN-10 in combination with 2-deoxy-D-glucose.
10/2011Involvement of endoplasmic reticulum stress-mediated CHOP (GADD153) induction in the cytotoxicity of 2-aminophenoxazine-3-one in cancer cells.
2/2011Rapid decrease of intracellular pH associated with inhibition of Na+/H+ exchanger precedes apoptotic events in the MNK45 and MNK74 gastric cancer cell lines treated with 2-aminophenoxazine-3-one.
1/20112-Aminophenoxazine-3-one and 2-amino-4,4α-dihydro-4α,7-dimethyl-3H-phenoxazine-3-one cause cellular apoptosis by reducing higher intracellular pH in cancer cells.
3/20102-Aminophenoxazine-3-one induces cellular apoptosis by causing rapid intracellular acidification and generating reactive oxygen species in human lung adenocarcinoma cells.
1/2008Apoptosis induction preceded by mitochondrial depolarization in multiple myeloma cell line U266 by 2-aminophenoxazine-3-one.
4/2006Anticancer effects of phenoxazine derivatives combined with tumor necrosis factor-related apoptosis-inducing ligand on pancreatic cancer cell lines, KLM-1 and MIA-PaCa-2.
5/20052-amino-phenoxazine-3-one attenuates glucose-induced augmentation of embryonic form of myosin heavy chain, endothelin-1 and plasminogen activator inhibitor-1 in human umbilical vein endothelial cells.

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Xiao-Fang Che Research Topics

Disease

22Neoplasms (Cancer)
02/2021 - 12/2002
5Breast Neoplasms (Breast Cancer)
02/2021 - 09/2008
5Multiple Myeloma
02/2015 - 01/2008
4Stomach Neoplasms (Stomach Cancer)
01/2022 - 02/2011
4Colonic Neoplasms (Colon Cancer)
09/2013 - 05/2007
4Hypoxia (Hypoxemia)
09/2013 - 02/2003
3Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
01/2021 - 05/2015
3Leukemia
10/2011 - 02/2003
3Carcinoma (Carcinomatosis)
05/2010 - 09/2008
2Carcinogenesis
01/2019 - 01/2019
2Hepatocellular Carcinoma (Hepatoma)
12/2018 - 02/2012
2Pancreatic Neoplasms (Pancreatic Cancer)
01/2016 - 04/2006
2Lung Neoplasms (Lung Cancer)
10/2011 - 03/2010
2Squamous Cell Carcinoma (Epidermoid Carcinoma)
05/2010 - 09/2007
1Retinoblastoma (Glioblastoma, Retinal)
06/2022
1Disease Progression
02/2021
1Neoplasm Metastasis (Metastasis)
12/2020
1Lymphatic Metastasis
12/2020
1Triple Negative Breast Neoplasms
01/2020
1Adenocarcinoma
01/2019
1Glioblastoma (Glioblastoma Multiforme)
11/2013
1Adenocarcinoma of Lung
03/2010
1Acute Promyelocytic Leukemia
09/2007
1Menkes Kinky Hair Syndrome (Menkes Disease)
05/2007
1Lymphoma (Lymphomas)
06/2006
1Adult T-Cell Leukemia-Lymphoma (Leukemia Lymphoma, T Cell, Acute, HTLV I Associated)
06/2006

Drug/Important Bio-Agent (IBA)

93-aminophenoxazoneIBA
11/2013 - 05/2005
5Angiogenesis Inducing Agents (Angiogenesis Factor)IBA
09/2013 - 02/2003
5Thymidine PhosphorylaseIBA
05/2010 - 02/2003
4Bortezomib (Velcade)FDA Link
02/2015 - 03/2011
3Proteins (Proteins, Gene)FDA Link
06/2022 - 07/2013
3Phosphotransferases (Kinase)IBA
06/2022 - 03/2006
3Reactive Oxygen Species (Oxygen Radicals)IBA
01/2020 - 03/2010
3Clarithromycin (Biaxin)FDA LinkGeneric
01/2016 - 07/2013
3phenoxazineIBA
01/2011 - 04/2006
3Complementary DNA (cDNA)IBA
05/2010 - 02/2003
3Fluorouracil (Carac)FDA LinkGeneric
05/2010 - 09/2008
3ThymidineIBA
05/2008 - 02/2003
3multidrug resistance-associated protein 1IBA
10/2005 - 12/2002
2Protein Kinases (Protein Kinase)IBA
06/2022 - 03/2006
2Cyclin D1IBA
06/2022 - 02/2021
2Interleukin-6 (Interleukin 6)IBA
01/2022 - 01/2019
2Messenger RNA (mRNA)IBA
02/2021 - 05/2005
2Biomarkers (Surrogate Marker)IBA
02/2021 - 12/2020
2Flap EndonucleasesIBA
02/2021 - 01/2020
2LigandsIBA
01/2021 - 04/2006
2Biological ProductsIBA
12/2020 - 08/2020
2Arsenic Trioxide (Trisenox)FDA Link
01/2020 - 09/2007
2MacrolidesIBA
01/2016 - 02/2015
2Gefitinib (Iressa)FDA Link
01/2016 - 05/2015
2Proteasome InhibitorsIBA
02/2015 - 07/2013
2major vault proteinIBA
09/2013 - 10/2008
2Sucrose (Saccharose)IBA
09/2013 - 10/2008
2ATP dependent 26S protease (26S proteasome)IBA
05/2013 - 03/2011
2Caspase 3 (Caspase-3)IBA
03/2011 - 05/2008
2Pharmaceutical PreparationsIBA
03/2010 - 05/2007
2Irinotecan (Camptosar)FDA LinkGeneric
05/2007 - 10/2005
2Member 1 Subfamily B ATP Binding Cassette TransporterIBA
10/2005 - 04/2003
2cepharanthineIBA
06/2005 - 06/2003
1Cyclin EIBA
06/2022
1Cyclin AIBA
06/2022
1Retinoblastoma ProteinIBA
06/2022
1Cyclin B1IBA
06/2022
1TamoxifenFDA LinkGeneric
02/2021
1atezolizumabIBA
01/2021
1EnzymesIBA
01/2020
1DNA Methyltransferase 3AIBA
01/2019
1bufalinIBA
01/2019
1Cytoplasmic DyneinsIBA
01/2019
1chan su (ChanSu)IBA
01/2019
1Long Noncoding RNAIBA
12/2018
1Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
05/2015
1Anti-Bacterial Agents (Antibiotics)IBA
02/2015
1Proteasome Endopeptidase Complex (Proteasome)IBA
02/2015
1UbiquitinIBA
02/2015
1JNK Mitogen-Activated Protein KinasesIBA
11/2013
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
09/2013
1Peroxisome Proliferator-Activated Receptors (PPAR)IBA
09/2013
1VorinostatFDA Link
07/2013
1Deoxyglucose (2 Deoxy D glucose)IBA
02/2012
1ThapsigarginIBA
10/2011
1TunicamycinIBA
10/2011
1Transcription Factor CHOPIBA
10/2011
1ChromatinIBA
02/2011
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
05/2010
1Thrombospondin 1IBA
10/2008
1Angiogenesis InhibitorsIBA
10/2008
1arseniteIBA
09/2007
1P-type ATPasesIBA
05/2007
1Vincristine (Oncovin)FDA LinkGeneric
05/2007
1Paclitaxel (Taxol)FDA LinkGeneric
05/2007
1Antineoplastic Agents (Antineoplastics)IBA
05/2007
1CopperIBA
05/2007
1Doxorubicin (Adriamycin)FDA LinkGeneric
05/2007
1Etoposide (VP 16)FDA LinkGeneric
05/2007
1PhosphatidylserinesIBA
04/2006

Therapy/Procedure

7Drug Therapy (Chemotherapy)
01/2021 - 06/2006
4Therapeutics
02/2021 - 02/2011
3Aftercare (After-Treatment)
10/2011 - 03/2010
1Chinese Traditional Medicine (Traditional Chinese Medicine)
01/2019